This Directive and the accompanying Instruction establish the authorities,responsibilities, requirements, and procedures for Biosafety in all activities conducted or sponsored by the Department of Homeland Security (OHS). This Directive adopts the principles of the current edition of the U.S. Health and Human Services Centers for Disease Control and Prevention and National Institutes of Health Biosafety in Microbiological and Biomedical Laboratories and its recommendations for standards, practices, equipment, and facilities for biological laboratory activities, as well as the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines) and other related guidance listed in Part Ill.